Is circovirus DNA infectious?

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The US Food and Drug Administration does not want Rotarix, the rotavirus vaccine, to be used because it contains porcine circovirus 1 DNA. If complete copies of the circovirus genome were present, would they constitute a potential threat to recipients? Put another way, is circovirus DNA infectious?

Here is the information you need to answer this question.

  • The circovirus genome is a circular, single stranded DNA molecule (pictured).
  • To infect a cell, the two viral proteins encoded in the DNA must be produced.
  • To produce proteins, mRNA must be synthesized from the viral DNA.
  • Single-stranded DNA cannot be copied  into mRNA; the DNA must be double-stranded.
  • The circovirus particle consists of a protein shell surrounding the viral DNA. There are no other components in the virion.
  • During infection of cells by circoviruses, the particles enter the nucleus where the viral DNA is released
  • If naked DNA is added to cells, a good fraction ends up in the nucleus.

Knowing these facts, can you determine whether introduction of circovirus DNA into cells would lead to viral replication?


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